research_liver_heatmapA fluxomics method based on in vivo NMR spectroscopy is being used in Jeffrey MacDonald’s laboratory to measure metabolic fluxes in tissues and organs. In collaboration with these experimental investigations, we are developing a mathematical model to simulate glycine metabolism in the liver. The model will be used to gain insight into the control mechanisms that regulate liver metabolism and also predict the dynamics of metabolic fluxes under novel experimental conditions.


(In collaboration with Ke Xu, Kevin Morgan at Sanofi-aventis U.S. and  Shawn Gomez)