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Principal Investigator

Tim ElstonTim Elston
Professor
telston@med.unc.edu
I am interested in understanding the dynamics of complex biological systems, and developing reliable mathematical models that capture the essential components of these systems.

Graduate Students

Keith Breau
CellBiology & Physiology Graduate Student
kbro9@email.unc.edu
I am interested in stem cell differentiation, cell polarity, and collective migration. I study the human intestinal epithelium, where a dedicated pool of rapidly-dividing stem cells transition into migrating differentiated cells in one of the most expansive examples of directed collective cell migration in the adult body.
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Alex Crocker
BCB Graduate Student

dinosaur@live.unc.edu
I study how fungi control the location and number of polarity sites in their cells, and how changes in cell polarity affect cell morphology and function.
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Elizabeth Davis
BCB Graduate Student
emae@med.unc.edu
Cell migration is a crucial aspect of many biological processes. External signaling guides cells through the detection of stimuli in the extracellular matrix (ECM) that influences their movement. The method of guided cell migration that I am studying is durotaxis, where cells preferentially move towards stiffer regions of the ECM where they are guided by local protrusions called pseudopods.
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Kaiyun (Kathy) Guan
BCB Graduate Student
kaiyun@live.unc.edu
My research focuses on mathematical modeling of signaling systems regulating cell polarity. My computational model centers on Rho GTPase Cdc42, which is the master regulator of cell polarity. I’m interested in how the combination of stochastic noise and different feedback systems, membrane trafficking, or extracellular chemical gradients affect the dynamics of Cdc42 during yeast polarization.
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Cody Herron
BCB Graduate Student
jcherron@unc.edu
I use mathematical modeling and image analysis techniques to examine the spatial and/or temporal organization of molecules in cells. In my research, I investigate podosome structure and organization, using the frustrated phagocytosis model to study podosome coordination,  and I explore conformational changes in Src and Talin observed using Binder Tag, a novel dual biosensor technique.
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Postdoctoral Fellows

Dey Anupam
Postdoctoral fellow
anupamd@email.unc.edu
Cell signalling pathways are complex in nature. How a cell responds to stimuli is quite fascinating. I am interested in understanding the complex cell signalling pathways involving G-proteins and developing mathematical models to understand the plant immune response to pathogen attack. I am also interested in understanding and modelling the signalling pathways in triple negative breast cancer.
Shuang Li
Postdoctoral fellow
shuang9@email.unc.edu
Sam Ramirez

Postdoctoral Fellow
sramirez@unc.edu
I’m currently investigating migration of mammalian cells guided by directional external stimuli. One project focuses on mathematical modeling and parameter inference to understand how a directional external cue induces biased cell motion. In another project I’m using modern image analysis tools based on machine learning to understand how cell morphology and cell deformation determines cell motility.
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Research Associate

Sandy Hahn
Research Associate
sshahn@email.unc.edu
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Alumni

  • Richard Allen
    Research Scientist, Pfizer
  • Marcelo Behar
    Assistant Professor, University of Texas at Austin
  • John Fricks
    Assistant professor of Statistics, Penn State University
  • Yan Fu
    Data Scientist at Kforce Inc.
  • Guilherme Garcia
    Assistant Professor, Medical College of Wisconsin

  • Mike Goedeke
    Research Triangle Institute, NC

  • Nan Hao
    Assistant Professor, University of California, San Diego

  • John Houser
    Postdoctoral Fellow, University of Texas, Austin

  • Meng Jin
    Postdoctoral Fellow, University of California, San Diego

  • Josh Kelley
    Assistant Professor, University of Maine

  • Kevin Kesseler
    AdderStone Predivtive Analytics

  • Vinal Lakhani
    Postdoctoral Fellow, Nationwide Children’s Hospital, Columbus OH

  • Kang-Ling Liao
    Assistant Professor, Department of Mathematics, Tamkang University

  • Patrick McCarter
    Postdoctoral Fellow, UNC-CH

  • Callie Miller
    Professor, James Madison Univeristy

  • Maria Minakova
    Facebook

  • Jason Pirone
    Biomathematician, SRA International, Inc., Durham, NC.

  • Conner Sandefur
    Assistant Professor, UNC Pembroke

  • Adrian Serohijos
    Assistant Professor, University of Montreal

  • Wanda Strychalski
    Assistant Professor, Department of Mathematics, Case Western Reserve University

  • Abby Todd
    Professor at Greenville College, Illinois

  • Denis Tsygankov
    Assistant Professor at The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory Universities

  • Sai Venkatapurapu
    Immunetrics

  • Xiao Wang
    Assistant Professor, School of Biological and Health Systems Engineering, Arizona State University

  • Necmettin Yildrim
    Assistant Professor, New College of Florida
  • Peiying Zuo 
    Glaxo Smith Kline
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